In addition, little skin irritation was found in the irritation study. The in vivo absorption curve obtained by deconvolution approach using WinNonlin® program was correlated well with the in vitro permeation curve, the correlation coefficient R is 0.84, and the result indicated that in vitro skin permeation experiments were useful to predict the in vivo performance. Zolmitriptan could be detected with drug level of 88 ± 51 ng/mL after transdermal administration of 15 min. The results revealed that the absolute bioavailability was about 63%. and transdermal administrations using animal model of rabbit. Pharmacokinetic parameters were determined via i.v. A sufficient cumulative penetration amount of zolmitriptan (258.5 ± 26.9 μg/cm(2) in 24 h) was achieved by the formulation of 4% zolmitriptan, 10% Azone, and adhesive of DURO-TAK® 87-4098. Solvent evaporation technique prepared zolmitriptan patch was settled in two-chamber diffusion cell combined with excised rabbit abdomen skin for permeation study. The objective of the present study was to develop transdermal patch for zolmitriptan, determine its in vivo absorption using the rabbit skin.
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